Many indigenous peoples have developed knowledge and practices for living with ecological complexity. Indicators and systems of monitoring based on the local and traditional knowledge of the Denesoline and Gwich'in of northern Canada were investigated. Through collaborative case study research we identified indicators of community health, ecosystem health, social-ecological health and ecological variability. Denesoline health indicators are framed around the Dene way of life and the journeys of self-government, healing and cultural preservation. Many different kinds of ecosystem health indicators are used by the Denesoline for understanding and communicating about variability and change in wildlife body condition, wildlife abundance, distribution and diversity, water quality, cultural landscapes and land features were also identified. Gwich'in berry picking activities were the basis for the study of social-ecological health; indicators identified related to individual and family health, social connectivity, cultural continuity, land and resource use, stewardship, self-government and spirituality. The berry picking case study also revealed indicators of ecological variability including species related (e.g. timing/rate of maturation of berries), regional (e.g. temperature), local (e.g. habitats) and site specific indicators (e.g. soil conditions). In addition to indicators, the Denesoline developed a system for monitoring caribou movements using key water crossings known to be bifurcation points to aid them in subsistence harvesting. Monitoring also helps Gwich'in berry pickers make decisions about where, when and with whom to harvest berries. Knowledge generated through monitoring, about variability, appears to be interrelated with the management of this commons resource. Locally developed "rules-in-use" for resource access, sharing information and harvest sharing seem to mirror the relative predictability of the species and also change in response to the abundance and distribution of berries across the region. How can this kind of traditional knowledge be included in resource management decision-making? Legislation and obligations defined in Supreme Court rulings have created clear opportunities in processes such as environmental assessment, however, even where no legal requirements exist, the culture of co-management created in settled land claim areas seems to have had a spill-over effect into non-settled claim areas. Informal arrangements also appear to increase awareness about the value of Aboriginal participation and traditional knowledge.